Buster Bunny's mission is to trace down and defeat Montana Max, who has stolen and hidden some treasure, and rescue Babs Bunny. Many foes are in the way, including Roderick Rat and Dr. Gene Splicer, who has brainwashed several of Buster's friends, including Plucky Duck, Dizzy Devil and Calamity Coyote. Upon defeating Gene, the helmet controlling Buster's friends will fall off and explode, leaving them dazed or to fall down in a comical fashion (in the case of Calamity Coyote).
To complete each level, Buster must find Gogo Dodo, who will allow him to enter a portal. Additionally, Buster can find portals reminiscent of the show's rainbow-colored logo, that will take Buster into Wackyland in the form of a bonus level. Here, Buster must attempt to collect as many items as he can before touching one of the numerous Dodos that populate the level.