A mild-mannered man is sent by his wife to go out and kill a duck for dinner. He ends up picking Daffy as his victim. The two face off and do battle for the remainder of the cartoon, only for Daffy to end up losing to Mr. Meek with him blowing his feathers off and cooking him in the oven. Just before the cartoon ends, as Mr. Meek hears Daffy screams in the oven he fells guilty and opens the oven door. The cartoon ends with Daffy bathing himself in gravy ("Say. Now you're cooking with gas.").
Some TV versions that aired on local affiliate stations in the United States shorten the part where Daffy (as a fortuneteller) hits Mr. Meek on the head with a mallet so he can read the bumps on his head, similar to ABC's censorship on a similar scene from "Bowery Bugs".
Cartoon Network's Arabia channel cuts the entire part where Daffy stripteases to distract Mr. Meek (since this scene is considered inappropriate in Arabic countries which uses Islam as its main religion).
"The Wise Quacking Duck" was the only color cartoon of the 1942-43 season to use the black and white fonts of WARNER BROS. and Present. It is also the only color Looney Tune in 1943 under copyright as Yankee Doodle Daffy, Daffy - The Commando, and To Duck or Not to Duck are in the public domain in the United States.