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Headquartered in Tampa, Florida, the hospitals, known as "The World's Greatest Philanthropy," are owned and operated by Shriners International, formerly known as the Ancient Arabic Order of the Nobles of the Mystic Shrine, a Freemasonry-related organization simply known today as the Shriners. Patients must be minors under the age of 18 and are not required to have any familial affiliation with the Shriners order nor Freemasonry.
Originally, the Looney Tunes starred in a PSA special titled "An Ounce of Prevention." The PSA special was later cut down and broadcasted as 3 separate PSA commercials.