The premise of her cartoons are centered around the fact that the other hens are ridiculing Prissy. Her first appearance was in the 1950 short An Egg Scramble, the only cartoon featuring her and Porky Pig, in which the other hens are making fun of the fact that she cannot lay an egg (because she think it's embarrassing). This particular cartoon is especially amusing, because Prissy takes on 2 voice talents. First, Mel Blanc takes on the role with his male-based high pitched "Yuh-essssss!!", which is Prissy's catchphrase. In one or two lines where she runs after the egg, Bea Benaderet steps in and voices her with "My egg!". Bea also voices the other hens who tease Prissy using all her famous dialects: the Brooklyn Girl, the "Betty Rubble" (including the infamous giggle), and the deep voice matron-like dialect.
Her next appearances are centered around Foghorn Leghorn. Lovelorn Leghorn (1951), she is set on finding a husband and Of Rice and Hen (1953) she is looking to have children. However, in Little Boy Boo (1954) she is depicted as a widow with a child Egghead Jr. and with a much more extensive vocabulary in long sounding words than her trademark "yeeeesss". In A Broken Leghorn (1959) and Strangled Eggs (1961), it is usually Foghorn who is pursuing Prissy for his own selfish needs