In Search of Tweetums, Part 2 is the twenty-sixth and final episode of Loonatics Unleashed. It first aired on May 5, 2007. It is the second part of the story that started in the previous episode, The Fall of Blanc, Part 1.
After receiving a message containing clues on Tweetums' whereabouts, the Loonatics and Sylth Vester seek out where Tweetums is located. Meanwhile, General Deuce and Optimatus begin their plans to conquer the universe. However, Deuce betrays Optimatus, who joins up with Zadavia and the Loonatics. During the final battle between Deuce and Ace, Ace banishes him to another universe. The episode ends with the Loonatics realizing they have graduated from merely protecting Acmetropolis, and are now protectors of the entire universe. The team decides to relocate their headquarters to Planet Blanc, which will allow them to instantly reach any troubled location anywhere in space.