Granny has gone through several design changes. The earliest version of Granny can be seen in the 1937 cartoon Little Red Walking Hood. This design was changed in 1943 with the release of Hiss and Make Up. She then received several other make-overs in 1940 to 1960, as is shown in cartoons such as Canary Row (1950) and A Pizza Tweety Pie (1958). Granny is the owner of Tweety Bird and also serves as his protector. Sylvester The Cat often finds a way to break in Granny's house for the sole purpose of finding a meal. In later cartoons, Granny appears to be the owner of both Tweety and Sylvester. Granny appears to be unmarried, or maybe a widow, since she obviously lives by herself.
In modern Looney Tunes media, Granny is still active, having made appearances in Space Jam, Tweety's High Flying Adventure (where she was once again the caretaker of the yellow canary), and Looney Tunes: Back in Action. She takes care of the other Looney Tunes animals in Baby Looney Tunes and also appeared in The Looney Tunes Show.
- Bea Benaderet: 1937 - 1953
- June Foray: 1953 - present
- GeGe Pearson: (It's Nice to Have a Mouse Around The House)
- Joan Gerber: (Corn on the Cop)