The short subjects introduces to the audience a tour of the United States, with recurring checks on the progress of the human fly climbing the Empire State Building. Also featured in this short subject are jokes and gags on the Everglades, the Wyoming prairies, Alaska, a California prospector, Sioux Indians and a Jerry Colona-esque (literal) Texas cow-puncher. In the end, the narrator and the audience check back on the human fly, who has almost made it to the top of the Empire State Building. When the narrator tells him to say a word to the audience, he yells "HELP!"
A poor, black hitchhiker at the North Pole, singing "Carry Me Back to Ol' Virginny", and an Eskimo sends him back by taking him all the way back to the Virginia state line.
Although the Native American segment is not removed entirely (there had been rumors that it was, but those were proven false), only one scene from the segment is cut: An Indian mother dealing with the dopey, oversized, adult son she's carrying on her back.
Detouring America's original ending card was never released on any home video format, but the original ending titles do exist on the censored a.a.p. print.
This cartoon is the second to feature the WARNER BROS. font without the yellow banner. The first is "Wise Quacks". This would be another prototype WARNER BROS. design. This is also one of three cartoons to have WARNER BROS. not on a banner with the 1938-39 Color Rings.