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ButtonsButtons, a heroic Lassie-like dog (voiced by Frank Welker), he is sworn to protect, even at the cost of severe injury to himself. The comedy of their shorts is based on the premise that, no matter what, Mindy always ends up exactly where her mother leaves her at the start of the skit, having narrowly avoided death a half dozen times, while the heroic (and severely battered) Buttons gets berated by Mindy's clueless parents (who have no idea of the trouble Mindy frequently gets into due to not paying the attention to her that they should, or of Buttons' attempts to save her) for some minor damage he or Mindy causes (e.g. trampling a flower bed) while trying to keep Mindy alive. The characters of this cartoon are similar to Baby Herman and Roger Rabbit. Wakko's Wish shows the only known time in which Mindy referred to her mother as "Mom" and Buttons received a reward (a stack of T-Bone Steaks) from Mindy's Mom rather than being scolded.
Mindy is the adorable and very beautiful little girl that Buttons must watch. She appears in the cartoon skit known as "Buttons and Mindy." Her mother always leaves her alone in the house with Buttons. Mindy always calls her mother "lady" and her father "Mr. Man". Mindy's curiosity always gets her and Buttons into very interesting (and in Mindy's case, life-endangering) situations. Mindy was voiced by Nancy Cartwright.