Acmegeddon Part I is the twelfth episode of Loonatics Unleashed. It first aired on May 6, 2006.
An mysterious alien known only as Optimatus, recruits four of the Loonatics' old enemies, Mallory Mastermind, Sypher, Weathervane, and Massive, in order to capture the Loonatics and place a chip inside their headquarters. They follow his orders, and end up in combat against the Loonatics. At the same time Zadavia attempts to warn them of the new villain that's lurking after these villains, and the Loonatics discover a secret from their past.